Role of C3a in Regulating Thymocyte Infection by HIV-1
نویسندگان
چکیده
The complement system is a crucial element of innate immunity and is involved in several processes related to host-pathogen defense mechanisms including during HIV-1 infection [1,2]. The complement system consists of over 30 soluble and membrane-bound proteins and is activated by three distinct pathways in response to the presence of pathogens [3,4]. In each instance the products of these pathways result in cleavage of complement system components C3 and C5 to yield the small peptides C3a and C5a. C3a and C5a function as anaphylatoxins, binding to G-protein coupled membrane receptors that, among several actions, sensitize the response of human T-lymphocytic cells to XCXL12/SDF-1 [5,6].
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